河南医学高等专科学校学报

目的 基于数据挖掘，分析门波教授治疗多囊卵巢综合征(polycystic ovary syndrome, PCOS)合并痤疮的用药规律，总结其临床经验及学术思想。方法 收集整理2023年1月—2023年12月门波教授治疗PCOS合并痤疮的门诊病例，通过中医传承辅助平台(V3.5)分析其用药规律。结果 纳入PCOS合并痤疮处方共63首，使用药物63种，药物使用总频次为1 033次，用药频次≥40的中药共10味，以川芎、黄芪、丹参、黄芩、茯苓、苍术、薏苡仁、桂枝、黄柏以及甘草为门波教授临床诊治PCOS合并痤疮的核心中药。药性以温性为主，甘、苦、辛为主要药味，归经以脾经居多。关联规则分析显示，两药关联规则分析置信度位列前4位分别为黄芪→川芎、苍术→川芎、丹参→茯苓、桂枝→川芎，三药关联规则分析置信度位列前3位分别为苍术、黄芩→川芎、薏苡仁、茯苓→川芎及黄芩、丹参→黄芪。基于聚类分析，获得5组潜在新处方。结论 门波教授认为，PCOS合并痤疮多以肾虚、脾虚为本，以肝郁、痰湿、血瘀为标。通过健脾除湿、化痰通络、疏肝活血、调补肾之阴阳等调理气血，标本兼顾，顺应月经周期规律临证加减，达到恢复“肾-天癸-冲任-胞宫”生殖轴的目的。

Objective To analyze the medication rules of Professor Men Bo in the treatment of polycystic ovary syndrome(PCOS) complicated with acne based on data mining, and summarize his clinical experience and academic thoughts.Methods Outpatient cases of Professor Men Bo in the treatment of PCOS complicated with acne from January 2023 to December 2023 were collected and sorted out, and the medication rules were analyzed through the Traditional Chinese Medicine Inheritance Assistance Platform(V3.5). Results A total of 63 prescriptions for PCOS complicated with acne were included, with 63 kinds of drugs used. The total frequency of drug use was 1 033 times. There were 10 traditional Chinese medicines with a medication frequency ≥40 times, including Chuanxiong(Rhizoma Chuanxiong), Huangqi(Radix Astragali), Danshen(Radix Salviae Miltiorrhizae), Huangqin(Radix Scutellariae), Fuling(Poria), Cangzhu(Rhizoma Atractylodis), Yiyiren(Semen Coicis), Guizhi(Ramulus Cinnamomi), Huangbai(Cortex Phellodendri), and Gancao(Radix Glycyrrhizae), which were the core traditional Chinese medicines used by Professor Men Bo in the clinical diagnosis and treatment of PCOS complicated with acne. The medicinal properties were mainly warm, the main flavors were sweet, bitter, and pungent, and the meridian tropism was mostly the spleen meridian. Association rule analysis showed that the top 4 confidence levels in the two-drug association rule analysis were Huangqi→Chuanxiong, Cangzhu→Chuanxiong, Danshen→Fuling, and Guizhi→Chuanxiong. The top 3 confidence levels in the three-drug association rule analysis were Cangzhu and Huangqin→Chuanxiong, Yiyiren and Fuling→Chuanxiong, and Huangqin and Danshen→Huangqi. Based on cluster analysis, 5 groups of potential new prescriptions were obtained.Conclusion Professor Men Bo believes that PCOS complicated with acne is mostly based on kidney deficiency and spleen deficiency, with liver depression, phlegm-dampness, and blood stasis as the secondary aspects. By invigorating the spleen and removing dampness, resolving phlegm and dredging collaterals, soothing the liver and activating blood, and regulating the yin and yang of the kidney to regulate qi and blood, both the root and branch are considered. Clinical modifications are made according to the laws of the menstrual cycle to achieve the goal of restoring the “kidney-Tiangui-Chongren-uterus” reproductive axis.